Acoustic characteristics of laser-induced plasmas from the forming dynamics perspective.

The acoustic signal has demonstrated its capabilities in assisting laser-induced breakdown spectroscopy (LIBS) measurements. In this study, the acoustic characteristics of laser-induced plasmas (LIPs) under different levels of energy deposition were analyzed, and their correlation with LIP forming dynamics was investigated. In the deposited energy space, two zones in the acoustic pressure and duration were observed, featuring a clear transition point in 100 mJ. The analysis based on self-emission spectra and images suggested that this transition is a result of the change in plasma forming dynamics. Above 100mJ, the plasma temperature and electron density were saturated; thus, any further increase in deposited energy only contributes to the plasma size. In this regime, the acoustic wave from the significantly elongated plasma no longer satisfied the ideal spherical assumption. The observation was also strengthened by the analysis in the frequency domain. Moreover, the correlation between acoustic and radiation signals was also changed significantly with plasma forming dynamics. This study offers a systematic analysis of LIP acoustic signals on the deposited energy space. The potential of using acoustic measurement to interpret the plasma forming dynamics was demonstrated, which could be beneficial for the successful implementations of acoustic-aided LIBS.

Photocatalytic Ag/AgBr-MBG for Rapid Antibacterial and Wound Repair.

In daily life and during surgery, the skin, as the outermost organ of the human body, is easily damaged to form wounds. If the wound was infected by the bacteria, especially the drug-resistant bacteria such as methicillin-resistant staphylococcus aureus (MRSA), it was difficult to recover. Therefore, it was important to develop the safe antimicrobial strategy to inhibit bacterial growth in the wound site, in particular, to overcome the problem of bacterial drug resistance. Here, the Ag/AgBr-loaded mesoporous bioactive glass (Ag/AgBr-MBG) was prepared, which had excellent photocatalytic properties under simulated daylight for rapid antibacterial activity within 15 min by generating reactive oxygen species (ROS). Meanwhile, the killing rate of Ag/AgBr-MBG against MRSA was 99.19% within 15 min, which further reduced the generation of drug-resistant bacteria. In addition, Ag/AgBr-MBG particles could disrupt bacterial cell membranes, showing the broad-spectrum antibacterial properties and promoting tissue regeneration and infected wound healing. Ag/AgBr-MBG particles might have potential applications as a light-driven antimicrobial agent in the field of biomaterials.

Monitoring the deposited energy in laser-induced plasmas with an acoustic approach.

The monitoring of energy deposition behavior during the plasma formation process is the basis of recently developed laser-induced breakdown thermometry techniques. Utilizing the acoustic waveforms from laser-induced plasmas, a method to monitor the deposited energy was proposed. The linear relationships between the acoustic energy and the deposited energy were established under four different focal lengths. After the distortions in the sound propagation were corrected, the applicable range of this method was extended to a deposited energy from 10 to 240 mJ. The further spectra analysis in the deposited energy space suggested that the total number density of excited species increased with the deposition energy, without significant fluctuations in plasma temperature in the high-energy region.

Degradable and self-luminescence porous silicon particles as tissue adhesive for wound closure, monitoring and accelerating wound healing.

Tissue adhesives have received much attention for their effectiveness in sealing wounds or incisions in clinical surgery, especially in minimally invasive surgery. To meet the safe and smart wound management requirements, ideal tissue adhesives are expected to have high biocompatibility, and be able to accelerate wound closing and healing, and monitor wound healing process. However, few adhesives fit all of the above descriptions. It has been demonstrated that inorganic nanoparticles can directly glue biological tissue based on nano-bridging effect. In this study, self-luminescence porous silicon (LPSi) particles were prepared with degradable and biocompatible properties. In addition, the self-luminescence property of LPSi particles was discovered by In Vivo Imaging System (IVIS) for the first time, which can avoid the limitations of photoluminescence imaging. Due to the oxidation and degradation reaction, LPSi particles not only can be degraded completely in several days, but also showed satisfactory biocompatibility. And their degradation product could promote tube formation of HUVECs. Moreover, owing to the high specific surface area and the outer oxide layer of LPSi particles, LPSi tissue adhesive exhibited strong adhesive strength to pig livers. Furthermore, this adhesive closed wound rapidly, promoted angiogenesis and epidermal regeneration, and facilitated wound healing in a mouse skin incision model. Importantly, the wound healing ratio can be monitored by measuring the self-luminescence intensity of LPSi particles in the wound site. This study reveals that LPSi particles could be employed as a safe and smart wound management tissue adhesive for wound closure, as well as accelerating and monitoring wound healing.

Gelatin-based adhesive hydrogel with self-healing, hemostasis, and electrical conductivity.

As a kind of natural protein derived material, gelatin has been widely used in the preparation of medical hydrogels due to its good biocompatibility, non-immunogenicity and the ability of promoting cell adhesion. Functionalization of gelatin-based hydrogels is a hot topic in research and its clinic application. Herein, a novel gelatin-based adhesive hydrogel was prepared via mussel-inspired chemistry. Gelatin was firstly functionalized by dopamine to form dopamine grafted gelatin (GelDA). After the mixture with 1,4-phenylenebisboronic acid and graphene oxide (GO), the GelDA/GO hydrogels were obtained by H2O2/HRP (horseradish peroxidase) catalytic system. Based on the self-healing and tissue adhesion of the hydrogels, the hemostatic property has been exhibited in the rat hepatic hemorrhage model. Additionally, the incorporation of GO endowed conductivity and enhanced the mechanical property of GelDA/GO hydrogels. The electromyography (EMG) signals of finger movement were successfully monitored by using hydrogel as the adhesive electrodes of EMG monitor. L929 cell experiments showed that the hydrogels had good cytocompatibility. The results indicated the potential application of GelDA/GO hydrogels in tissue adhesives, wound dressings, and wearable devices.

Study on hemostatic effect and mechanism of starch-based nano-microporous particles.

The powdered hemostatic particles have broad application prospects in large open wounds, internal organ injuries and penetrating injuries of the body. In this study, nanoscale mescoporous and macroporous silica (MMSN), nanoscale mescoporous and macroporous bioactive glass (MBG), micron-scale cross-linked corn starch porous microspheres (CMS), MMSN@CMS and MBG@CMS starch-based nano-microporous particles were synthesized and their hemostatic effect and hemostatic mechanism were studied. The results showed that comparted with the single particle of CMS, the combination particles MBG@CMS and MMSN@CMS significantly increased the water absorption rate, activated both internal and external coagulation pathways, significantly shortened CBT, as well as the improved hemostatic effects in vitro. The immediately released Ca2+ from MBG@CMS in the blood to participate in the coagulation pathway, and MMSN@CMS activated platelets by concentrating blood coagulation factors, might be the main hemostatic mechanisms for the starch-based nano-microporous particles. Furthermore, the hemostatic efficacy of particles, both in the model of tail-amputation and liver injury in SD rats, showed the starch-based nano-microporous particles, especial MBG@CMS, could significantly reduce the weight of blood loss and shorten the bleeding time. Our research work stated that the starch-based nano-microporous particles MBG@CMS might be a hemostasis biomaterial with the potential applications for the emergency bleeding.

Stakeholder Analysis and Social Network Analysis in the Decision-Making of Industrial Land Redevelopment in China: The Case of Shanghai.

Currently, many large Chinese cities have entered the postindustrial era, leaving a large amount of vacant, inefficiently utilized industrial land and buildings in the inner cities. Industrial land redevelopment (ILR) can benefit cities in multiple ways, such as by increasing urban public space, improving the quality of life of citizens, and improving the environment, and is considered an effective approach to enhance people's wellbeing. However, large-scale ILR projects often raise a series of social issues in practice, such as injustice and inequality. To address complex urban issues, ILR requires multifaceted, coordinated, and comprehensive strategies involving multitudinous stakeholders. A profound understanding of diverse stakeholders in the decision-making of ILR is a vital step in enhancing the sustainability of ILR. The aim of this paper is to use Shanghai as a case study to understand the diverse stakeholders and their participation during the decision-making of ILR in China. Interviews and questionnaires were used to collect data. Stakeholder analysis (SA) and social network analysis (SNA) were used as complementary research methodologies in this paper. First, stakeholders who participated in the decision-making of ILR were identified. Then, the characteristics of various stakeholders, including power, interests, and knowledge, were analyzed. Following this, the interactive relationships among stakeholders were explored, and their network structure was examined. Finally, policy recommendations were presented regarding stakeholder participation problems in the decision-making of ILR in China.

Research status and development potential of composite hemostatic materials.

Bleeding is a serious incident that can occur in people's daily lives or clinics. Bleeding can be caused by accidental trauma, surgery, congenital diseases, or blood disorders caused by drugs. Excessive bleeding in the body can lead to illness or death. Adequate hemostasis is an essential strategy to prevent bleeding to avoid death and is the first step in wound healing. With rapid developments in science and technology, various hemostatic materials have been developed with the hope of enhancing the hemostatic effect by activating different coagulation mechanisms. Some examples are the formation of physical barriers, platelet aggregation, concentration of blood components, and release of clotting factors. The design of composite hemostatic materials should conform to the requirement according to which multiple coagulation mechanisms can be simultaneously activated in order to enhance the hemostatic effect. Combined with the research status of composite hemostatic materials, it has been found that there is still a lack of materials that exhibit high biocompatibility, shape variability, simultaneous usability for both internal and external bleeding, in vivo degradability, ability to camouflage platelets or blood cells, and other clotting-related factors. Therefore, the future development potential and optimization direction for composite hemostatic materials have been proposed through an in-depth discussion on their characteristics and coagulation mechanisms. It is hoped that this review can provide a worthwhile reference for research into hemostatic materials.